Collect	A clean-catch, mid-stream, fresh voided urine is optimal as a screen for bladder cancer. 50 ml is adequate. Add one volume of Saccomanno’s fixative (which contains mixed alcohols and 2% polyethylene glycol) to the sample at the time of collection
	Remarks	If microbiology and urinalysis is needed, split off part of the sample before adding fixative since the fixative is not compatible with these other tests. Avoid sampling during a clinical urinary infection, as the urothelium will be diluted with inflammatory cells. A 24-hour urine is not satisfactory for diagnosis because the cells will be degenerated. Two or three samples on different days have been shown to boost sensitivity of the test. UroVysion FISH for bladder cancer is available on urine submitted in Saccomanno fixative, with or without morphological evaluation. Indicate whether UroVysion FISH testing is desired directly on the cytology requisition.
	Notes	All specimens must have two forms of patient identification on them and be accompanied by a Cytology Requisition that includes the patient name, medical record number, source of specimen and the submitting physician’s name. Slides must be labeled with the patient’s name and medical record number (if available) using a pencil. An adequate clinical history including pertinent lab/x-ray findings is essential. Missing information may result in a delay of the pathology report. Supplies listed below are available from the General Stores or the Cytology Laboratory. Submit all specimens including night and weekend specimens to Central Processing.

88112 *The CPT codes provided are based on the AMA guidelines and for informational purposes